Gerhard Klebe Selected Research

queuine tRNA-ribosyltransferase

1/2022	19F-NMR Unveils the Ligand-Induced Conformation of a Catalytically Inactive Twisted Homodimer of tRNA-Guanine Transglycosylase.
10/2021	Unraveling a Ligand-Induced Twist of a Homodimeric Enzyme by Pulsed Electron-Electron Double Resonance.
1/2021	Targeting a Cryptic Pocket in a Protein-Protein Contact by Disulfide-Induced Rupture of a Homodimeric Interface.
1/2020	Fragment Screening Hit Draws Attention to a Novel Transient Pocket Adjacent to the Recognition Site of the tRNA-Modifying Enzyme TGT.
1/2018	Swapping Interface Contacts in the Homodimeric tRNA-Guanine Transglycosylase: An Option for Functional Regulation.
1/2017	Soaking suggests "alternative facts": Only co-crystallization discloses major ligand-induced interface rearrangements of a homodimeric tRNA-binding protein indicating a novel mode-of-inhibition.
1/2015	Replacement of water molecules in a phosphate binding site by furanoside-appended lin-benzoguanine ligands of tRNA-guanine transglycosylase (TGT).
9/2013	High-affinity inhibitors of Zymomonas mobilis tRNA-guanine transglycosylase through convergent optimization.
1/2013	Launching spiking ligands into a protein-protein interface: a promising strategy to destabilize and break interface formation in a tRNA modifying enzyme.
12/2009	How to replace the residual solvation shell of polar active site residues to achieve nanomolar inhibition of tRNA-guanine transglycosylase.

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Gerhard Klebe Research Topics

Disease

16	Bacillary Dysentery (Shigellosis) 01/2022 - 03/2009
9	Malaria 08/2015 - 01/2004
5	Diabetes Complications 01/2017 - 07/2004
3	Foodborne Diseases 01/2015 - 07/2012
2	Multiple Sclerosis 01/2022 - 01/2018
2	Rupture 01/2021 - 10/2006
2	Neoplasms (Cancer) 12/2015 - 03/2014
2	Infections 07/2007 - 07/2007
1	Breast Neoplasms (Breast Cancer) 01/2022
1	Bone Diseases (Bone Disease) 11/2020
1	Hemorrhage 01/2020
1	Chagas Disease (American Trypanosomiasis) 01/2020
1	Phenylketonurias (Phenylketonuria) 01/2018
1	Osteoarthritis 01/2016
1	Lung Neoplasms (Lung Cancer) 12/2015
1	Hypertension (High Blood Pressure) 08/2015
1	Mycoses (Diseases, Fungus) 08/2015
1	Alzheimer Disease (Alzheimer's Disease) 08/2015
1	Chronic Disease (Chronic Diseases) 10/2012
1	Inflammation (Inflammations) 11/2011
1	Cataract (Cataracts) 05/2009
1	Bacterial Infections (Bacterial Infection) 09/2007
1	Dysentery 07/2007
1	Glaucoma 01/2004

Drug/Important Bio-Agent (IBA)

16	EnzymesIBA 01/2022 - 07/2007
12	queuine tRNA-ribosyltransferaseIBA 01/2022 - 03/2009
6	Aldehyde Reductase (Aldose Reductase)IBA 01/2017 - 07/2004
5	Pharmaceutical PreparationsIBA 12/2015 - 07/2004
4	LigandsIBA 10/2021 - 10/2006
3	Proteins (Proteins, Gene)FDA Link 01/2021 - 03/2009
3	Transfer RNA (tRNA)IBA 01/2018 - 10/2009
3	Peptide Hydrolases (Proteases)FDA Link 08/2015 - 09/2008
2	Sorbitol (Yal)FDA Link 12/2015 - 05/2009
2	Hemoglobins (Hemoglobin)IBA 03/2010 - 09/2008
2	Farnesyltranstransferase (Farnesyltransferase)IBA 08/2008 - 01/2004
2	Glucose (Dextrose)FDA LinkGeneric 11/2007 - 05/2007
2	polyolIBA 11/2007 - 05/2007
2	fosmidomycinIBA 09/2007 - 05/2005
1	DisulfidesIBA 01/2021
1	Diphosphonates (Bisphosphonates)IBA 11/2020
1	NitrogenIBA 11/2020
1	Thrombin FDA Link 01/2020
1	farnesyl pyrophosphate (farnesyl diphosphate)IBA 01/2020
1	AnticoagulantsIBA 01/2020
1	Factor XIII (Coagulation Factor XIII)IBA 01/2020
1	sapropterin (tetrahydrobiopterin)FDA Link 01/2018
1	matriptaseIBA 01/2016
1	Serine Proteases (Serine Protease)IBA 01/2016
1	Retinaldehyde (Retinal)IBA 12/2015
1	ReninIBA 08/2015
1	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 08/2015
1	Secreted Aspartic ProteasesIBA 08/2015
1	GuanineIBA 11/2012
1	RNA (Ribonucleic Acid)IBA 11/2012
1	7-(aminomethyl)-7-deazaguanineIBA 11/2012
1	queuine (Q base)IBA 11/2012
1	AminesIBA 10/2012
1	PolyestersIBA 10/2012
1	Shiga Toxin (Shigella Toxin)IBA 07/2012
1	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA 11/2011
1	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 11/2011
1	Monoclonal AntibodiesIBA 07/2007
1	EpitopesIBA 07/2007
1	AnionsIBA 07/2007
1	zopolrestatIBA 10/2006
1	Peptides (Polypeptides)IBA 10/2006
1	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 01/2004

Therapy/Procedure

3	Therapeutics 01/2022 - 01/2004
3	Drug Therapy (Chemotherapy) 11/2020 - 10/2014